Hypoxia-inducible factor 1 alpha (HIF-1α) orchestrates cellular adaptation to low oxygen and nutrient-deprived environment and drives progression to malignancy in human solid cancers. Its canonical regulation involves prolyl hydroxylases (PHDs), which in normoxia induce degradation, whereas in hypoxia allow stabilization of HIF-1α. However, in certain circumstances, HIF-1α regulation goes beyond the actual external oxygen levels and involves PHD-independent mechanisms. Here, we gather and discuss the evidence on the non-canonical HIF-1α regulation, focusing in particular on the consequences of mitochondrial respiratory complexes damage on stabilization of this pleiotropic transcription factor.
CITATION STYLE
Iommarini, L., Porcelli, A. M., Gasparre, G., & Kurelac, I. (2017, November 27). Non-canonical mechanisms regulating hypoxia-inducible factor 1 alpha in cancer. Frontiers in Oncology. Frontiers Media S.A. https://doi.org/10.3389/fonc.2017.00286
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