Novel Cocrystals of Glipizide: Green Supramolecular Mechanosynthesis

Abstract

The present research demonstrates the five novel cocrystals of glipizide (GPZ) with picolinic acid (PA), adipic acid (AA), isonicotinic acid (INA), fumaric acid (FA) and sorbic acid (SRA). The cocrystals were prepared via green supramolecular mechanosynthesis approach and exhibited 1:1 stoichiometric ratio. The cocrystals were characterized by thermal (DSC) and spectroscopic (PXRD, FTIR and SSNMR) techniques. PXRD data was used to elucidate the crystal structure. GPZ-PA, GPZ-AA, GPZ-INA, GPZ-FA and GPZ-SRA were found to be crystallized in triclinic and monoclinic crystal systems, which exist in P-1, P1 and P21 space groups. Remarkable improvement in solubility and intrinsic dissolution rate (IDR) was observed along with significant reduction in rat blood serum glucose level and high Cmax in comparison to GPZ.