Deep diving in the blood stem cell‐ome

Abstract

Defining the functional distinctions between cells comprising the bone marrow has yielded fundamental insights into lineage ordering and drivers of blood cell production. A novel, highly granular and multi-dimensional molecular characterization of functional subsets of hematopoietic stem- and progenitor cells recently published in Cell Stem Cell (Cabezas-Wallscheid et al,) will serve as a landmark and treasure trove for unanticipated insights into basic biology and the development of future targeted medicine. An integrated -omics analysis of hematopoietic stem- and progenitor populations offers unprecedented insights into their regulatory networks at the molecular, cellular and epigenetic level.