Spectrophotometric estimation of aripiprazole in tablets

Abstract

A simple, sensitive and rapid spectrophotometric method has been developed for the determination of aripiprazole in pharmaceutical formulations. The proposed method is based on the oxidation of drug with N-bromosuccinimide and unreacted N-bromosuccinimide bleaches the blue color of methylene blue and is measured at 663 nm. The increase in absorbance is directly proportional to the aripiprazole concentration and obeys Beer-Lambert’s law in the range of 5-20 μg/ml. The molar absorptivity and Sandell’s sensitivity, of the method were found to be 1.4906×104 l/mol/cm, 0.0300 µg/cm2, respectively. No interference was observed from excipients commonly found in tablets.