Linkage of fifty-seven microsatellite loci to bipolar disorder

Abstract

ITIT authors' goal was to screen for genetic linkage with mghly infonnative deoxyribonucleic acid (DNA) Urosatellite markers on a series of moderately sized HDrth American bipolar disorder (BP) pedigrees. These IP pedigrees were genotyped with 57 short tandem-rrptIlt polymorphic systems (microsatellites) that were tcymIltiCllly amplified from genomic DNA. We did not significant evidence for genetic linkage. We found isolated LOD scores greater than 2 on chromosome 1 at two loci in individual pedigrees. Simulation studies for multiple analyses under the assumptions of linkage and nonlinkage were performed. The simulations show that LOD scores greater than 2 could be expected even when linkage is absent. Significance levels need to be considered carefully in systematic linkage studies. © 1993, American College of Neuropsychopharmacology. All rights reserved.