Filamin A interaction with GPIbα: The platelet shapes up

Abstract

In this issue, Nakamura and colleagues report the x-ray crystal structure of filamin A repeat 17 with a peptide from the cytoplasmic tail of GPIbα, an interaction fundamental to platelet size and shape, as well as the functional activity of the GPIb-IX-V complex, the platelet von Willebrand factor adhesion receptor.