Synthesis of meso- tetrakis (2-chloroquinolin-3-yl) porphyrins

Abstract

meso-Tetrakis (-2-chloroquinolin-3-yl) porphyrins were synthesized from 2-chloroquinoline-3-carboxaldehydes and pyrrole in 1:1 ratio in propionic acid at 140 °C for 4 hours. Different substituted 2-chloroquinoline-3- carboxaldehydes were synthesized from corresponding N-aryl acetamides by Vilsmeier-Haack cyclization. The aldehydes were obtained in better yields, when acetamides, dimethyl formamide and POCl3 were taken in 1:3: 7 molar ratios at 70-75 °C. © ARKAT USA, Inc.