OC-006 Influence of BMI and Alcohol on Liver-Related Morbidity and Mortality in a Cohort of 108,000 Women from the General Population from Ukctocs

Abstract

Background and Aims: Alcohol and fat are major causes of chronic liver disease (CLD), however their relative influences are not well understood. We aimed to determine liver-related morbidity and mortality attributable to fat and alcohol by stratifying a cohort of 202,638 women according to BMI and alcohol intake. Methods: 107,742 women participating in the UK Collaborative Trial of Ovarian Cancer Screening where self-reported height, weight and alcohol intake were available were included. First episode related to cirrhosis (ICD-10 codes K70, K73, K74) either from inpatient Hospital Episode Statistics or death certification was recorded following entry to the trial. Participants were stratified by low or high BMI (<25 or >25 kg/m2), low or high alcohol intake (0-15 or over 15 units/week) and combinations of these parameters. (Table presented) Results: Median age at recruitment was 60 years (50-75). Mean BMI was 26.4 kg/m2. There were 90 events (54 inpatient episodes and 36 deaths). There was no difference in risk of event between BMI groups. Risk was significantly increased in the high alcohol group (Log-Rank <0.001). Cox proportional hazards regression analysis (covariates age, BMI and alcohol intake), found that compared to the low BMI/low alcohol group, there was an incremental increase in risk of event in the high BMI/low alcohol, low BMI/high alcohol and high BMI/high alcohol groups respectively. Only the combination of high BMI and high alcohol reached significance (table and figure). Conclusions: The combination of high alcohol intake and high BMI interact synergistically to produce an increased risk of CLD. Alcohol may be the more significant contributing factor. Further work is required to define thresholds for each risk factor that independently and in combination increase risk of CLD.