Anticuerpos monoclonales contra el CGRP para el tratamiento de la migraña crónica y episódica

Abstract

Migraine is a clinical condition that causes neurological disability in a high percentage of the economically active population. This disorder is characterized by pulsatile unilateral headache accompanied by other neurovascular phenomena. The disease can acquire a chronic behavior forcing patients to receive preventive treatment for a long time period. However, many drugs currently available for the chronic treatment cause different side effects that limit their use and most of them were not designed specifically for migraine prevention. Evidence of the role that calcitonin gene related peptide (CGRP) plays in the mechanisms of central sensitization and in the physiopathology of migraine has led to the development of therapies directed to limit its biological activity, among which there are four new monoclonal antibodies against that molecule or its receptor. Clinical trials carried out so far with these antibodies provide evidence in favor of their use in the treatment and control of migraine, therefore, in this review we discuss the results of such studies and provide the physiological and molecular bases that support the use of the CGRP as a therapeutic target. (English) [ABSTRACT FROM AUTHOR]