An invivo study on the hepato-protective effects of Crocus sativus, Ziziphus jujuba and Berberis vulgaris against acute acetaminophen and rifampicin-induced hepatotoxicity

Abstract

Drugs are an important cause of liver injury. The use of natural remedies for the treatment of liver diseases has a long history and medicinal plants are still used all over the world for this purpose. For their medicinal and nutritional values, Berberis vulgaris, Crocus sativus and Ziziphus jujuba plants are of particular interest. In current study we aim to explore hepato-protective effects of three medicinal plants; C.sativus (petal and stigma), Z.jujuba and B.vulgaris in acute drug-induced hepatotoxicity and evaluation of their preventive effects in acetaminophen and rifampicin-induced hepatotoxicity in rat.