Direct catalytic intermolecular α-allylic alkylation of aldehydes by combination of transition-metal and organocatalysis

Abstract

(Chemical Equation Presented) All in the same pot together: The direct catalytic α-allylic alkylation of aldehydes and cyclic ketones is achieved by using a simple, unprecedented one-pot procedure. Transition-metal and enamine catalysis are combined so that α-allylic alkylated aldehydes and cyclic ketones are formed in high yield with a direct catalytic chemo- and regioselective method. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.