The biosynthesis of the macrolide antibiotic lucensomycin

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Abstract

The biosynthesis of lucensomycin in cultures of Streptomyces lucensis has been studied using 14C-labelled precursors. The aglycone arises from two propionate and twelve acetate units. One propionate unit provides the chain-initiating unit, whilst the second, involved in chain-extension, undergoes oxidation of its methyl group to form the free carboxyl function of the aglycone. © 1969, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

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Manwaring, D. G., Rickards, R. W., Gaudiano, G., & Nicolella, V. (1969). The biosynthesis of the macrolide antibiotic lucensomycin. The Journal of Antibiotics, 22(11), 545–550. https://doi.org/10.7164/antibiotics.22.545

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