A robust, efficient, and highly enantioselective method for synthesis of homopropargyl amines

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Abstract

Fast, robust, selective: Copper-catalyzed enantioselective additions of homopropargyl groups to a wide range of aldimines proceed readily and with high enantioselectivity. The catalytic method is scalable and practical, the allenylboron reagent is commercially available, and conversion into amines is inexpensive and high-yielding. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Vieira, E. M., Haeffner, F., Snapper, M. L., & Hoveyda, A. H. (2012). A robust, efficient, and highly enantioselective method for synthesis of homopropargyl amines. Angewandte Chemie - International Edition, 51(27), 6618–6621. https://doi.org/10.1002/anie.201202694

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