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Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein

Nature Communications (2020) 11(1)
DOI: 10.1038/s41467-020-19146-5
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Abstract

The CR3022 antibody, selected from a group of SARS-CoV monoclonal antibodies for its ability to cross-react with SARS-CoV-2, has been examined for its ability to bind to the ectodomain of the SARS-CoV-2 spike glycoprotein. Using cryo-electron microscopy we show that antibody binding requires rearrangements in the S1 domain that result in dissociation of the spike.

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APA

Wrobel, A. G., Benton, D. J., Hussain, S., Harvey, R., Martin, S. R., Roustan, C., … Gamblin, S. J. (2020). Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein. Nature Communications, 11(1). https://doi.org/10.1038/s41467-020-19146-5

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