Influence of Surfactant Concentration on Mesoporous Bioactive Glass Scaffolds with Superior in Vitro Bone-Forming Bioactivities

Abstract

Hierarchically 3D porous mesoporous bioactive glasses (MBGs) saffolds with advantages of both macroporosity and mesoporosity have been successfully synthesized through evaporation-induced self-assembly (EISA) in the presence of a nonionic block copolymer EO100PO65EO100 (F127) and polyurethane (PUF) as co-templates. Higher pore volume and uniform mesopore sizes are formed when F127 concentration over the critical micelle concentration (CMC). After soaking these MBGs scafflds in simulated body fluid (SBF) for 4 h, it can be observed that the formation of hydroxyl apatite (HAP) on the surface of the MBG scaffolds.