Abstract
The combined hexane/CH2Cl2 extract of the stem bark of Teclea gerrardii (Rutaceae: Toddalioideae) has yielded two acridone alkaloids, 3-hydroxy-1-methoxy-N-methylacridone (tegerrardin A) (1) and 3-hydroxy-N-methyl-1-(γ,γ-dimethylallyloxy)acridone (tegerrardin B) (2), three known acridones (3-5), two known furoquinolines (6,7), and the acridone precursor tecleanone (8). Arborinine (3) and evoxine (6) displayed moderate antiplasmodial activity against the CQS D10 strain of Plasmodium falciparum, with IC50 values of 12.3 and 24.5 μM, respectively. © 2006 Elsevier Ltd. All rights reserved.
Author supplied keywords
- 1,3-Dimethoxy-N-methylacridone
- 3-Hydroxy-1-methoxy-N-methylacridone (tegerrardin A)
- 3-Hydroxy-N-methyl-1-(γ,γ-dimethylallyloxy)acridone (tegerrardin B)
- 7-(γ,γ-Dimethylallyloxy)-γ-fagarine
- Acridone alkaloids
- Antiplasmodial activity
- Arborinine
- Evoxanthine
- Evoxine
- Furoquinoline alkaloids
- Plasmodium falciparum
- Rutaceae
- Stem bark
- Teclea gerrardii
- Tecleanone
Cite
CITATION STYLE
Kamdem Waffo, A. F., Coombes, P. H., Crouch, N. R., Mulholland, D. A., El Amin, S. M. M., & Smith, P. J. (2007). Acridone and furoquinoline alkaloids from Teclea gerrardii (Rutaceae: Toddalioideae) of southern Africa. Phytochemistry, 68(5), 663–667. https://doi.org/10.1016/j.phytochem.2006.10.011
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