Advances in micropillar arrays in cellular biomechanics detection and tissue engineering

Abstract

Cellular biomechanical features contributed to the occurrence and development of various physiological and pathological phenomena. Micropillar arrays have emerged as an important tool for both the assessment and manipulation of cellular biomechanical characteristics. This comprehensive review provides an in-depth understanding of the fabrication methodologies of micropillar arrays and their applications in deciphering and fine-tuning cellular biomechanical properties and the innovative experimental platforms including organ-on-a-chip and organoids-on-a-chip. This review provides novel insights into the potential of micropillar technology, poised to update the landscape of stem cell research and tissue engineering.