LGR5-Positive Supporting Cells Survive Ototoxic Trauma in the Adult Mouse Cochlea

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Abstract

Sensorineural hearing loss is mainly caused by irreversible damage to sensory hair cells (HCs). A subgroup of supporting cells (SCs) in the cochlea express leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5), a marker for tissue-resident stem cells. LGR5+ SCs could be used as an endogenous source of stem cells for regeneration of HCs to treat hearing loss. Here, we report long-term presence of LGR5+ SCs in the mature adult cochlea and survival of LGR5+ SCs after severe ototoxic trauma characterized by partial loss of inner HCs and complete loss of outer HCs. Surviving LGR5+ SCs (confirmed by GFP expression) were located in the third row of Deiters’ cells. We observed a change in the intracellular localization of GFP, from the nucleus in normal-hearing to cytoplasm and membrane in deafened mice. These data suggests that the adult mammalian cochlea possesses properties essential for regeneration even after severe ototoxic trauma.

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APA

Smith-Cortinez, N., Yadak, R., Hendriksen, F. G. J., Sanders, E., Ramekers, D., Stokroos, R. J., … Straatman, L. V. (2021). LGR5-Positive Supporting Cells Survive Ototoxic Trauma in the Adult Mouse Cochlea. Frontiers in Molecular Neuroscience, 14. https://doi.org/10.3389/fnmol.2021.729625

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