Abstract
l-Tryptophan (Trp), melatonin (MLT) and the Trp-peptide pentagastrin quenched the formation of azidyl radicals generated on irradiation of the anticancer complex trans,trans,trans-[Pt(pyridine)2(N3)2(OH)2] with visible light, giving rise to C3-centred indole radicals which were characterized for Trp and MLT using an EPR spin-trap; indole, together with azidyl and hydroxyl radicals, have potential roles in a multitargeting mechanism of action against resistant cancers.
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CITATION STYLE
Vallotto, C., Shaili, E., Shi, H., Butler, J. S., Wedge, C. J., Newton, M. E., & Sadler, P. J. (2018). Photoactivatable platinum anticancer complex can generate tryptophan radicals. Chemical Communications, 54(98), 13845–13848. https://doi.org/10.1039/C8CC06496B
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