Studi Penambatan Molekul Senyawa Turunan Fenilpropanoid Pada Tumbuhan Lengkuas (Alpina galangal (L.) Willd.) Sebagai Obat Antikanker Otak

Abstract

Brain cancer is a malignant tumour can grow and spread aggressively, overpowering healthy cells by taking their possition, blood, and nutrients. Galangal is one of the typical Indonesian plants whose compounds have been studied showing activity as anti-inflammatory and antioxidant which became pioner of anticancer activity. The purpose of this study is to obtain candidates for new compounds as brain anticancer from phenylpropanoid derivatives so that it can be an alternative source of medicinal materials through molecular docking method. All phenylpropanoid derivatives were docked to the target receptor by using the AutoDock Tools program. Validation of method did gave the value of Root Mean Square Deviation (RMSD) is 0,804Å. Analysis of the molecular docking result showed that galanganol C compound can be predicted to have the most well interaction with an energy bond value of-12,69 kcal/mol than the temozolomide comparator drug of-5,90 kcal/mol. PreADME test were