Bur1/Bur2 and the Ctk complex in yeast: The split personality of mammalian P-TEFb

52Citations
Citations of this article
38Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Eukaryotic organisms possess a host of factors that regulate transcriptional elongation. In higher eukaryotes, the transcription factor P-TEFb not only regulates phosphorylation of the RNA polymerase II C-terminal domain, but it also inhibits the action of transcriptional repressors and is required for the association of several elongation factors with the transcribing polymerase. In the yeast Saccharomyces cerevisiae, the cyclin dependent kinases Bur1/Bur2 and Ctk complex (Ctk1, 2 and 3) are also able to impact several aspects of transcription. Together, these two kinase complexes appear to functionally reconstitute the activity of P-TEFb in yeast. Recent findings regarding the role of these kinases in histone tail modifications and transcriptional regulation is briefly reviewed below. ©2006 Landes Bioscience.

Cite

CITATION STYLE

APA

Wood, A., & Shilatifard, A. (2006, May 15). Bur1/Bur2 and the Ctk complex in yeast: The split personality of mammalian P-TEFb. Cell Cycle. Taylor and Francis Inc. https://doi.org/10.4161/cc.5.10.2769

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free