The Effect of Fasting on Haematology Serum Biochemistry Parameters on STZ Induced CD1 Mice and Diabetic db/db Mice

Abstract

Modest information is available on how fasting affects clinical pathology variables in (Streptozocin) STZ induced diabetes mice and db/db mice. This study was carried out to evaluate the influence of fasting on clinical pathology variables in diabetic mouse models. Seven male STZ induced diabetic CD1 mice and db/db mice were fasted for 18 hours and change in body weight (BW), hematologic and biochemical variables were evaluated. Fasting provoked significant variation in body weight, haematology and biochemical variables in diabetic animal models. The results suggested that clinical pathology variables will vary after fasting. The decision to feed or fast before blood collection for analyzing the results should be made based on fasting in animal models for diabetic research.