Anti-oxidant, anti-inflammatory and anti-cancer activities of avocado (Persea americana) fruit and seed extract

Abstract

Avocado (Persea americana) seeds represent under-utilised resources and waste issues in avocado processing. This study was produced to compare the lipid contents of the avocado bulb and seed. The study also evaluated the anti-oxidant, anti-inflammatory and anti-cancer potentiality of each extract. Oleic acid was the predominant unsaturated fatty acid in a chloroform/methanol extract of P. americana fruit and seed. The seed extract was richer with sterol compounds than the fruit extract. The extracts exhibited anti-inflammatory and anti-cancer activities against cell line of colon cancer (HCT116) and cell line of liver cancer (HePG2) in a dose-dependent manner. It also exhibited powerful scavenging of free radical by using- DPPH and ABTS. IC50 of seed extract against the aforementioned cancer cell lines was more or less near the values of a reference drug (sorafinib). In conclusion, P. americana seed extract has more powerful effects than avocado bulb extract. The seeds should not be neglected.