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Pulchranins B and C, new acyclic guanidine alkaloids from the far-eastern marine sponge Monanchora pulchra

Natural Product Communications (2013) 8(9) 1229-1232
DOI: 10.1177/1934578x1300800911
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Abstract

New marine natural products, pulchranins B and C (2 and 3), were isolated from the marine sponge Monanchora pulchra and their structures were established using NMR and MS analysis. Compounds 2 and 3 were moderately active as inhibitors of TRPV1 (EC50 value of 95 and 183 μM, respectively) and less potent against TRPV3 and TRPA1 receptors.

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Makarieva, T. N., Ogurtsova, E. K., Korolkova, Y. V., Andreev, Y. A., Mosharova, I. V., Tabakmakher, K. M., … Stonik, V. A. (2013). Pulchranins B and C, new acyclic guanidine alkaloids from the far-eastern marine sponge Monanchora pulchra. Natural Product Communications, 8(9), 1229–1232. https://doi.org/10.1177/1934578x1300800911

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