Evolution of some biochemical and hematological parameters of thalassemia patients in Maysan Governorate, Iraq

Abstract

Thalassemia is inherited anemia publicity that common in the world and especially in Mediterranean region, and the most important cause of mortality in patients. The study included (108) patients (males & females) with thalassemia in Amara city and (20) healthy individuals as a control group. All subjected to examination tests for assessment hematological parameters as well as liver functions tests.The results showedasignificant increase(p<0.01) in glutamic pyruvic transaminase (GPT), glutamic oxaloacetic transaminase (GOT),andAlkaline Phosphatase (ALP) in patients with thalassemia compared with healthy subjects, however, total bilirubin concentration(TSB) did not show significant difference.There are also a significant increases (p <0.01) in White blood cells (WBC) and Platelets (PLT), While Red blood distribution width (RDW) in thalassemia patients compared with healthy subjects,Red blood cell (RBC), Mean cell volume (MCV), Mean corpuscular hemoglobin (MCH), Mean concentration of hemoglobin (MCHC),Hemoglobin (Hb) showed significant decrease (P <0.01) in thalassemia patients compared with healthy subjects. In conclusion: liver enzymes GPT, GOT, and ALP were significantly higher in thalassemia patients, hematological parameters were contradictive when compared with healthy subjects.