Chronic hepatotoxicity of carbon tetrachloride in HSP-70 knock out mice

Abstract

The chronic hepatotoxic effects of carbon tetrachloride (CCI4) in heat-shock protein (HSP) 70 knock out (HSP70-/-) mice were examined. After repeated intraperitoneal injections of CCI4 for six weeks, the level of ALT and weight ratio of the liver to body were lower in HSP70-/- mice than in the control (WT) mice. The levels of HSP25 and HSP47 were lowered in HSP70-/- mice as compared with WT mice. The grades of hepatic necrosis and neutrophil infiltration were not significantly different between HSP70-/- and WT mice. The collagen content was not affected significantly by CCL4 treatment. Copyright © 2004 Japanese Association for Laboratory Animal Science.