Abstract
An efficient four-step synthesis of the novel receptor antagonist (MK-0679) of leukotriene D4 (LTD4) will be described. The key steps are enzymatic hydrolysis of prochiral diester to the ester-acid in 98% enantiomeric excess followed by aluminum mediated amidation of the methyl ester which affords MK-0679 in high overall yield. © 1992, IUPAC
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CITATION STYLE
APA
Shinkai, I., & Bhupathy, M. (1992). Chemoenzymatic synthesis of a novel LTD4 antagonist. Pure and Applied Chemistry, 64(8), 1177–1180. https://doi.org/10.1351/pac199264081177
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