The Adaptation of Two Human Coronavirus Strains (OC38 and OC43) to Growth in Cell Monolayers

Abstract

Two human coronaviruses, strains OC38 and OC43, were successfully adapted to growth in tissue culture monolayers. The adapted strains produced a cytopathic effect in primary rhesus or vervet monkey kidney and in BSC-1 cell monolayers. The adaptation described will facilitate further investigations of the structure of coronaviruses. © 1970, SAGE Publications. All rights reserved.