Isochromophilones I and II, Novel Inhibitors against gp120-CD4 Binding Produced by Penicillium multicolor FO-2338: II. Structure Elucidation

Abstract

The structures of isochromophilones I and II, new gp120-CD4 binding inhibitors isolated from a cultured broth of Penicillium multicolor FO-2338, were elucidated by NMR experiments. Both of compounds have an azaphilone skeleton substituted by a chlorine atom at C-5 and a side chain, 3, 5-dimethyl-1, 3-heptadien at C-3. Additionally, isochromophilone I has a y-lactone ring, and isochromophilone II has 2-oxopropyl moiety instead of a y-lactone ring. © 1995, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.