Generation of small-compound libraries via random chemistry by Fenton's reagent

Abstract

Re-combinatorial chemistry, an auspicious method for generating small-compound libraries by means of γ-irradiation of active lead compounds, disclosed the formation of new compounds with reassembled or rearranged structures mainly to be derived from radical chemistry. Therefore, Fenton's reagent was applied to a methanol/water solution of tacrine to mimic the irradiation. In fact, these preliminary studies revealed the generation of a small compound library with a product composition similar to those obtained by γ-irradiation. ©ARKAT USA, Inc.