Protein phosphatase 2A enables expression of interleukin 17 (IL-17) through chromatin remodeling

Abstract

Background: Increased PP2A levels have been linked to autoimmunity in SLE patients and transgenic mice. Results: In T cells, PP2A overexpression increases the transcription of proinflammatory genes and facilitates chromatin accessibility at the Il17 locus. Conclusion: Increased levels of PP2A promote the inflammatory capacity of T cells. Significance: PP2A dysregulation may contribute to SLE by directly affecting lymphocyte gene expression. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.