Antimicrobial Resistance Patterns and Beta-lactamases Producing of Carbapenem Resistant Klebsiella pneumonia Isolated from Iraqi Patients

Abstract

In this study, a total of 381clinical samples were collected from five hospitals in Baghdadduring the period July2018–January2019. The samples were cultured on MacConkey agarand blood agar plates to isolate Klebsiella Pneumonia in order to estimate its prevalence rate antimicrobial resistance patterns and Beta-lactamases produced. Outof 381 samples, 342 (89.8%) had Klebsiella pneumoniae. Thirty eight of342 of K .pneumoniaeisolateswere resistant to carbapenem (CRKP).A phenotypic detection of beta-lactamases showed that allCRKP isolatesdid not produceextended spectrum beta-lactamases.Whereas all these 38 isolates were produced metallo-betalactamases (MBLs).Regarding to antibiotic susceptibility test, these 38 CRKP isolates were resistant to 13of15antibioticsused in this study.Whereas 25 out of 38 CRKP isolates were sensitive to Levofloxacin. According to MIC values, the metallo-betalactamase producing CRKP isolates were resistance to 11 out of 15 antibiotics used. However,13 out of 38 CRKP isolates were resistant to levofloxacin.