The cytotoxic effect of PM 701 and its fractions on cell proliferation of breast cancer cells, MCF7

Abstract

Breast cancer is the most common malignancy in the world among women. Many therapies have been designed to treat this disease. Mamectomy, chemotherapy and radiotherapy are still the main therapies of breast cancer. However, the results were unsatisfactory and still far from the ideal treatment. PM 701 is a natural product, has anticancer activity. The bioactive fraction PMF and subfraction PMFK had been isolated from PM 701. PM 701 and its fractions were proved to have a cytotoxic properties against different cancer cell lines. This study is directed for the further examination of lyophilized PM 701 and its active fractions on the growth of breast cancer cells (MCF-7). PM 701, PMF or PMFK were adding to the cultural medium, where MCF-7 is incubated. PM 701, PMF or PMFK were able to inhibit significantly the proliferation of MCF-7 cells. These new agents were proved to induce apoptosis of the breast cancer cells; through its direct effect on the nuclei. © 2011 Academic Journals Inc.