Imatinib Mesylate, Increased Bone Formation, and Secondary Hyperparathyroidism

  • Grey A
  • O'Sullivan S
  • Reid I
  • et al.
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Abstract

The effect of starch gelatinization on electrical conductivity (σ) was investigated in this study. Suspensions of corn and potato starch were prepared with a starch:water ratio of 1:5 (w/w) by mixing with the appropriate amount of water. Suspensions were ohmically heated with agitation to 90°C by AC at 60 Hz, and a voltage gradient of 20 V/cm. Partially gelatinized and fully gelatinized samples, prepared by preheating suspensions to or beyond the gelatinization ranges, were also tested. Gelatinization energy (ΔHG) and degree of gelatinization (%SG) of each sample were determined by differential scanning calorimetry (DSC) at a scanning rate of 10°C/min. The results showed that endothermic gelatinization peaks were found on both DSC thermograms and electrical conductivity curves, with similar shapes and temperature ranges. Data of %SG obtained from conductivity curves and DSC thermograms were in agreement in low and mid-gelatinization ranges but were different when %SG was high, due to high ohmic heating rate. Electrical conductivity increased with temperature, but decreased with degree of gelatinization, apparently caused by structural changes and an increase in bound water. © 1998 Elsevier Science Limited. All rights reserved.

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Grey, A., O’Sullivan, S., Reid, I. R., & Browett, P. (2006). Imatinib Mesylate, Increased Bone Formation, and Secondary Hyperparathyroidism. New England Journal of Medicine, 355(23), 2494–2495. https://doi.org/10.1056/nejmc062388

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