A Review of Studies on Major Depressive Disorder

Abstract

The World Health Organization ranked major depression disorder (MDD) as the third largest burden of disease globally, and it is projected to become number one by 2030. Interest in pleasurable activities, guilt or worthlessness, low energy, poor concentration, altered appetite, low intelligence or restlessness, sleep disturbances, or suicidal thoughts can be diagnosed when a person's mood is persistently low or depressed, anhedonia or declining. MDD is more common in people without close interpersonal relationships, divorce or separation, or widowhood. The prevalence of MDD did not GABA differ between race and socioeconomic status. Individuals with MDD usually have comorbid disorders, such as substance use disorder, panic disorder, social anxiety disorder, and obsessive-compulsive disorder. The presence of these comorbidities in patients diagnosed with MDD increases their risk of suicide. Among the elderly, people with comorbid diseases generally suffer from depression. Depression is more common in rural areas than in urban areas.