A CLINICAL STUDY TO EVALUATE THE EFFICACY OF GUDUCHYADI KWATH IN THE MANAGEMENT OF DIABETIC POLYNEUROPATHY

Abstract

Incidence of diabetes is escalating globally and approximately 50 percent of patients with diabetes eventually develop neuropathy. The growing sideeffects of modern pharmacological agents are a persuasion to search an amicable solution in Ayurveda. A total of 60 patients of Diabetic Polyneuropathy aged between 20‐70 yrs were randomly selected and assigned in two groups. In Group A (Trail group) patients were given Guduchyadi Kwath, 40ml twice daily after meal while those in Group B (Control group) were given Tab Methylcobalamine (500mcg) + Gabapentine (300mg), 1 tab daily for 90 days with 6 follow ups. Assessment was done on the basis of sign and symptoms as mentioned in Ayurvedic and modern classics and objective parameters of Diabetic Neuropathy. It was observed that the resultant improvement in cardinal sign and symptoms were statistically highly significant for Burning sensation, Vibration sensation, Toronto clinical score (p<0.001) and significant for Numbness, Pin prick test (p < 0.05), Tingling sensation (p <0.01), Monofilament test (p< 0.02) while insignificant results were obtained for symptoms of Neuropathic pain, weakness and sign of deep tendon reflex for the Trail drug. On comparing the results obtained for both the groups it is observed that the trail drug, Guduchyadi kwath has equivalent efficacy in DPN as the control drug except for the symptom of neuropathic pain for which the control drug seems to be effective while the trail drug was observed to be ineffective.