Systemic and neuropathologic effects of E. Coli endotoxin in neonatal dogs

Abstract

The acute systemic and neuropathologic effects of E. coli endotoxin were determined in neonatal dogs. Administration of suble-thal (LD0), moderate (LD50), or lethal (LD100) doses of endotoxin produced significant arterial hypotension, metabolic (lactic) acidosis, and hypoglycemia. Neuropathologic changes consisted of widespread inflammation in both grey and white matter; however, necrotic lesions were found only in forebrain white matter. © 1983 International Pediatric Research Foundation, Inc.