Preparation of some pyrazoline derivatives and evaluation of their antifungal activities

Abstract

The synthesis of a new series of 1-[(benzazole-2-yl)thioacetyl]-3,5-diaryl- 2-pyrazoline derivatives was obtained by reacting 1-(chloroacetyl)-3,5-diaryl- pyrazolines with 2-mercaptobenzimidazole/benzoxazole/benzothiazole. The chemical structures of the compounds were elucidated by 1H-NMR, 13C-NMR, and FAB-MS spectral data. Their antifungal activities against Candida albicans, Candida glabrata, Candida utilis, Candida tropicalis, Candida krusei, and Candida parapsilosis were investigated. A significant level of activity was observed. © 2010 Informa UK Ltd.