Rapid progression of cardiomyopathy in mitochondrial diabetes

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Abstract

Cardiac involvement and its clinical course in a diabetic patient with a mitochondrial tRNA(Leu(UUR)) mutation at position 3243 is reported in a 54- year-old man with no history of hypertension. At age 46, an electrocardiogram showed just T wave abnormalities. At age 49, it fulfilled SV1 + RV(5 or 6)>35 mm with strain pattern. At age 52, echocardiography revealed definite left ventricular (LV) hypertrophy, and abnormally increased mitochondria were shown in biopsied endomyocardial specimens. He was diagnosed as having developed hypertrophic cardiomyopathy associated with the mutation. However, at age 54, SV1 and RV5,6 voltages were decreased, and echocardiography showed diffuse decreased LV wall motion and LV dilatation. Because he had mitochondrial diabetes, the patient's heart rapidly developed bypertrophic cardiomyopathy, and then it seemed to be changing to a dilated LV with systolic dysfunction. Rapid progression of cardiomyopathy can occur in mitochondrial diabetes.

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APA

Momiyama, Y., Atsumi, Y., Ohsuzu, F., Ui, S., Morinaga, S., Matsuoka, K., & Kimura, M. (1999). Rapid progression of cardiomyopathy in mitochondrial diabetes. Japanese Circulation Journal, 63(2), 130–132. https://doi.org/10.1253/jcj.63.130

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