Pineapple fruit extract (Ananas comosus L. Merr) as an antioxidant and anti-acne agent made with the nano-emulsion gel delivery system

Abstract

Background: Pineapple (Ananas comosus L. Merr) contains a lot of fibre, minerals, and vitamins. Consequently, it has anti-inflammatory, antibacterial, antioxidant, and antidiabetic benefits. Objective: The purpose of this research was to produce pineapple extracts in the form of nano-emulsion gel for more effective use as an antioxidant and anti-acne. Method: The extraction was done by maceration. The resulting extracts were formulated with tween 20 and propylene glycol, while kollisolv PYR served as the oil phase. A nano-emulsion was then formed and formulated into a gel. Result: In this study, the nano-emulsion gel produced was transparent yellowish-white, slightly viscous, with a characteristic odour, a particle size of 10.8 nm ± 0.5, a polydispersity index of 0.239 Ð ± 0.1 and a zeta potential of -33.6 mV ± 1.3. The ability of this nano-emulsion gel to spread was good, 10.28 cm - 14.48 cm, with 1.31 seconds of adhesion and the result of the viscosity test of 3667.4 ± 106.03 cP. In the antioxidant test, the %RSA was produced in the range of 17.70 - 70.32% and the IC50 value was 0.1 μg/mL so it was included in the category of very strong antioxidant. While the anti-acne test has an average bacterial inhibition zone of 10.5 mm ± 0.1 which is in the category of strong anti-acne. Conclusion: It was concluded that pineapple fruit extract with a nano-emulsion gel base can produce good nanoparticle preparations, which have very strong antioxidant and anti-acne activities.