AMELIORATIVE ANTIUROLITHIATIC EFFECT OF A POLYHERBAL SUSPENSION

Abstract

A polyherbal suspension was prepared for use in urolithiasis. Three drugs namely Cyperus rotundus roots, Azadirachta indica leaves and Bryophyllum pinnatum leaves were used in the formulation. Antiurolithiatic activity was studied in the ethylene glycol induced urolithiasis model at a dose of 100, 200 and 300mg/kg polyherbal suspension in wistar rats. Cystone was used as the standard drug. All the doses were found to be effective in a dose related manner. There was an increase in the urinary excretion of calcium, oxalate, phosphate, urea, uric acid and creatinine significantly in the suspension treated group. P<0.001was obtained when compared to control. The results show that the polyherbal suspension has prevented or decreased the supersaturation of urine leading to prevention of stone formation and agglomeration. The excretion of these ions was much lesser when compared to the negative control group. The dose of 300mg/kg of polyherbal suspension had activity quite similar to that of the standard drug cystone. Thus we conclude that the formulated polyherbal suspension has potential antiurolithiatic activity.Keywords: Antiurolithiatic activity, Cyperus rotundus,  Azadirachta indica, Bryophyllum pinnatum, Polyherbal suspension.