Antifungal activity of pyranone and furanone derivatives, isolated from Aspergillus sp. IFM51759, against Aspergillus fumigatus

Abstract

Thirty-five of 102 exts. obtained from freshly isolated fungal strains showed the antifungal activity against either pathogenic filamentous fungi or pathogenic yeasts. The ext. of Aspergillus sp. IFM51759 (Aspergillus versicolor group), which showed characteristic antifungal activity against Aspergillus fumigatus, one of the major opportunistic human pathogen causing allergenic bronchopulmonary aspergillosis (APBA) etc., prompted us to isolate antifungal compds. A new furanone deriv., epimusacin D (I), was isolated along with three known pyranone derivs., asperlin (II), acetylphomalactone (III), and IV, the diastereomer of II. The structure of I was detd. from anal. of spectroscopic investigation. The antifungal activity of the above four compds. were discussed. [on SciFinder(R)]