Incorporation of B and La oxides into bioactive glass: in vitro studies for bone regeneration applications

Abstract

Bone tissue engineering seeks to regenerate damaged tissues using biocompatible scaffolds that mimic bone minerals. This study focuses on scaffolds based 45S5 bioactive glass (45% SiO2, 24.5% Na2O, 6% P2O5, 24.5% CaO) doped with boron and lanthanum oxides. These scaffolds, produced via conventional melting, form a hydroxyapatite layer, promoting strong bone integration. Result of DTA, XRD, FTIR, SEM, and EDS, showed doping led to crystalline phase identification, silicate network confirmation, and detection of calcium phosphorus deposits. Doping also increased pH, degradation kinetics, and antibacterial activity. These findings suggest that boron and lanthanum-doped 45S5 scaffolds have potential in bone regeneration applications.