MP45-11 THE WATER STUDY CLINICAL RESULTS – RESULTS AT 1 YEAR AND URODYNAMIC FINDINGS.

Abstract

Introduction and Objectives: Early reports of Aquablation (robotic, high‐velocity waterjet prostate resection) for lower urinary tract symptoms due to benign prostatic hyperplasia suggest efficacy similar to that of TURP. We compare the safety and efficacy of prostate ablation using Aquablation (A) vs TURP (T). Methods: In this randomized, blinded, multi‐center phase III trial, men with moderate‐to‐severe LUTS related to BPH were assigned to TURP or Aquablation. The primary safety endpoint was the occurrence of persistent CD Grade 1 or Grade 2 or higher operative complications at 3 months. The primary efficacy endpoint was the reduction in IPSS score at 6 months. Here we report 12 month data. Results: The mean baseline IPSS score, demographic profile, and mean prostate volume (T: 52 mL vs. A: 54 mL, p = 0.31) were similar in both arms. Mean operative time was equivalent between the two groups (T: 35.5 vs. A:32.8 min, p = 0.28), but mean resection time was significantly less in the Aquablation group (27 vs. 4 min, p < .0001) compared to baseline for both arms) with no significant difference in decrease across groups (p = .8919). Conclusions: Aquablation showed noninferior symptom relief compared to TURP but with a lower risk of sexual dysfunction. The change in IPSS and Qmax at 12 months show similar durability for both Aquablation and TURP.