In vitro antifungal activity of the soap formulation of the hexane leaf extract of Morinda morindoides (Morinda; Rubiaceae)

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Abstract

Purpose: The aim of this study was to formulate the hexane extract of the leaves of Morinda morindoides (Baker) Milne-Redh (Rubiaceae) as soap and evaluate its antifungal activity against fungal isolates of human origin. Method: The hexane extract of Morinda morindoides was incorporated as an antifungal agent in soap (SMM) and tested against 4 strains of dermatophytes (Candida albicans, Trichophyton rubrum, Trichophyton mentagrophytes and Aspergillus fumigatus) using basic soap (BS) as control. Agar dilution method at serial concentrations ranging from 125 mg/ml to 3.9 mg/ml was used for the determination of the antimicrobial parameters - MIC (minimum inhibitory concentration) and IC50 (concentration producing 50% inhibition) for these strains. Result: The growth of all fungal strains tested was inhibited by the Morinda morindoides extract soap (SMM) at MIC of 31.25 mg/ml. On the other hand, basic soap (control) inhibited Candida albicans at MIC of 125 mg/ml and at MIC of 62.50 mg/ml for the other 3 strains tested. Thus, SMM showed stronger antifungal activity against the strains tested than the control (basic soap). Conclusion: The hexane extract of Morinda morindoides leaves incorporated in soap exerted antifungal activity against the fungal strains tested. Thus, this soap formulation may find use in the treatment of dermatomycoses. © Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria.

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APA

Touré, A., Bahi, C., Bagré, I., N’Guessan, J. D., Djaman, A. J., & Coulibaly, A. (2010). In vitro antifungal activity of the soap formulation of the hexane leaf extract of Morinda morindoides (Morinda; Rubiaceae). Tropical Journal of Pharmaceutical Research, 9(3), 237–241. https://doi.org/10.4314/tjpr.v9i3.56283

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