Abstract
Background: An increased glucagon/insulin ratio is known to contribute to hyperglycemia in diabetes. Results: NOX-G15, a mirror-image mixed DNA/RNA glucagon-neutralizing aptamer, was identified. It improved glucose tolerance in models of type 1 and 2 diabetes. Conclusion: NOX-G15 may be useful for treatment of type 1 and 2 diabetes. Significance: The new therapeutic candidate may help to reduce insulin need in diabetes. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
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CITATION STYLE
Vater, A., Sell, S., Kaczmarek, P., Maasch, C., Buchner, K., Pruszynska-Oszmalek, E., … Klussmann, S. (2013). A mixed mirror-image DNA/RNA aptamer inhibits glucagon and acutely improves glucose tolerance in models of type 1 and type 2 diabetes. Journal of Biological Chemistry, 288(29), 21136–21147. https://doi.org/10.1074/jbc.M112.444414
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