Efficacy of clopidrogel on reperfusion and high-sensitivity c-reactive protein in patients with acute myocardial infarction

Abstract

We investigated the effects of clopidogrel on reperfusion and inflammatory process in STEMI. A total of 175 STEMI patients with similar clinical characteristics were included to this study. One was the standard pharmacological reperfusion therapy group (group 1, n: 90), who received 300x2009;mg aspirin, 70x2009;U/kg bolus, and 12x2009;U/kg/hr continuous infusion of unfractioned heparin and accelerated t-PA. Clopidogrel 450x2009;mg loading and 75x2009;mg/d thereafter was added to standard reperfusion therapy in the other group (group 2, n: 85). The ST-segment resolution, CK-MB, and high-sensitive CRP (hs-CRP) parameters were measured. Complete ST resolution was observed in 32 patients (36.837;) in group 1 and 53 patients (63.837;) in group 2 (P