The effects of insulin and strontium ranelate on guided bone regeneration in Diabetic Rats

Abstract

The aim of this study was to investigate the effect of insulin and strontium ranelate treatment on guided bone regeneration in diabetic rats. This study was carried out on 30 adult Wistar rats with an average weight of 250-300 grams. The animals underwent a unilateral osteotomy of the left proximal tibia followed by bone augmentation with collagenized porcine bone xenografts (Osteobiol® mp3, Tecnoss Dental s.r.l., Torino, Italy) and then were randomized into five groups: healthy (H), diabetes (D), diabetes with insuline (DI), diabetes with strontium ranelate (DS) and diabetes with insuline and strontium ranelate (DIS). Histomorphometric analysis was performed at the end of this study.