Stellaria media attenuates the hyperglycemia and hyperlipidemia in alloxan-induced diabetic rat

Abstract

The aim of this research work was to assess the hyperglycemic and hyperlipidemic effects of Stellaria media in alloxan-induced diabetic rat using different experimental models. Standard documented protocols were used to concede the in vitro and in vivo activities. The results showed pancreatic αamylase and β-glucosidase inhibition in vitro at varying concentrations of the extract which further validated the in vivo anti-diabetic action of the plant. The administration of various concentrations of the extract showed decrease in fasting blood level when compared to diabetic control. Similarly, decreased HbA1c (−48.4%) were observed when compared to diabetic control rat. The extract also caused reduced serum transaminase and produced a succeeding recovery toward their normal values. In conclusion, the in vitro and in vivo hypoglycemic and hypolipidemic activity offer the methodical justification for the use of S. media in herb based anti-diabetic treatment.