Severe flare-up in a patient with Crohn’s disease and coinfection by SARS-CoV-2: Clinical approach and treatment

Abstract

Crohn’s disease is considered a chronic immune-mediated disease, which physiopathologically is characte-rized by being a multifactorial disease in which environmental and genetic factors intervene, among others. Patients have a risk to develop complications not only related to the disease, but also because of the medica-tion used to treat it. This risk plays a relevant role today due to the 2019 coronavirus disease, an infection that has been shown more serious in patients with comorbidities, which increases morbidity and mortality. In this study is analyzed a young man case with underlying Crohn’s disease with symptoms and signs of intestinal obstruction and systemic inflammatory response. He was admitted for the first time with a severe flare-up in the terminal ileum, compatible with perforation associated with local collection and secondary adynamic ileus and presents a co-infection with the severe acute respiratory syndrome type 2 coronavirus (SARS-CoV-2). The case presentation, discussion, and review of the literature on the diagnosis of a severe flare-up of Crohn’s disease and SARS-CoV-2 coinfection, clinical approach and treatment are carried out.